T cell exhaustion in parasitic infections - Takeaways - MDSpire
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Impairment of T cell Function in Chronic Parasitic Infections

  • By

  • Ge Gao

  • Hao Wang

  • Rafeezul Mohamed

  • Yinming Liang

  • September 4, 2026

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  • 1

    T cell exhaustion is a progressive functional impairment due to persistent antigenic stimulation in chronic parasitic infections.

  • 2

    Exhausted T cells exhibit increased expression of inhibitory receptors and altered metabolic activity compared to memory and effector T cells.

  • 3

    The hallmark of T cell exhaustion is the gradual loss of effector functions, including decreased production of key cytokines.

  • 4

    Exhausted T cells cannot achieve homeostatic proliferation due to lower expression of IL-7 and IL-15 receptors.

  • 5

    Understanding T cell exhaustion mechanisms is crucial for developing targeted immunotherapies for chronic parasitic infections.

Original Source(s)

T cell exhaustion in parasitic infections

  • by Ge Gao, Hao Wang, Rafeezul Mohamed, Yinming Liang

  • September 4, 2026

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