Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection - Takeaways - MDSpire

Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

  • By

  • Caroline Charre

  • Florence Buseyne

  • Adeline Mélard

  • Elise Gardiennet

  • Alice-Andrée Mariaggi

  • Thomas Montange

  • Jérôme Le Chenadec

  • Josiane Warszawski

  • Stéphane Blanche

  • Véronique Avettand-Fenoël

  • Pierre Frange

  • January 8, 2026

  • 0 min

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  • 1

    An adolescent with perinatal HIV-1 infection was treated from 1 month of age but exhibited negative serologies despite prolonged viremia.

  • 2

    The patient achieved sustained viral suppression at 4 years old after intensive adherence support and multiple cART modifications.

  • 3

    At 18 years, no intact proviruses were detected, although defective proviruses were present, indicating ongoing HIV reservoir challenges.

  • 4

    Immunologic assessments showed absent HIV-specific immune responses, suggesting limited adaptive immunity against the virus.

  • 5

    This case challenges current definitions of seroconversion and HIV persistence in children, highlighting complexities in early-treated infections.

Original Source(s)

Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

  • by Caroline Charre, Florence Buseyne, Adeline Mélard, Elise Gardiennet, Alice-Andrée Mariaggi, Thomas Montange, Jérôme Le Chenadec, Josiane Warszawski, Stéphane Blanche, Véronique Avettand-Fenoël, Pierre Frange

  • January 8, 2026

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