Efficacy and safety of low-dose thrombolysis in acute intermediate-high risk pulmonary thromboembolism complicated by PaO2/FiO2 < 300 - Takeaways - MDSpire

Efficacy and safety of low-dose thrombolysis in acute intermediate-high risk pulmonary thromboembolism complicated by PaO2/FiO2 < 300

  • By

  • Lei Liu

  • Congcong Li

  • Liang Shi

  • Debin Ma

  • Zhiyuan Zhang

  • Hongzhu Bao

  • Chunhua Li

  • Li Li

  • Min Wang

  • Zhuang Ma

  • Junli Zhang

  • July 9, 2026

  • 0 min

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  • 1

    The study evaluated low-dose alteplase thrombolysis in 96 patients with acute intermediate-high-risk pulmonary thromboembolism and PaO2/FiO2 ratio < 300 mmHg.

  • 2

    Both low-dose and conventional-dose thrombolysis groups showed significant improvements in PaO2/FiO2 ratio compared to the low-molecular-weight heparin group.

  • 3

    Minor bleeding was significantly lower in the low-dose thrombolysis group compared to the conventional-dose group, with no major bleeding events reported.

  • 4

    No significant differences were observed in hospital stay, ICU stay, costs, or chronic thromboembolic pulmonary disease at 3 months among the groups.

  • 5

    The study concluded that low-dose thrombolysis provided early improvements in oxygenation and hemodynamics, but lacked sufficient power to confirm differences in bleeding risk.

Original Source(s)

Efficacy and safety of low-dose thrombolysis in acute intermediate-high risk pulmonary thromboembolism complicated by PaO2/FiO2 < 300

  • by Lei Liu, Congcong Li, Liang Shi, Debin Ma, Zhiyuan Zhang, Hongzhu Bao, Chunhua Li, Li Li, Min Wang, Zhuang Ma, Junli Zhang

  • July 9, 2026

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