Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial - Takeaways - MDSpire

Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial

  • By

  • Yonghao Li

  • Yutong Wang

  • Ruikang Liu

  • Xuanchun Huang

  • Shiyi Tao

  • FuYuan Zhang

  • Jun Li

  • JingRun Cui

  • June 11, 2026

  • 0 min

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  • 1

    The study evaluates the efficacy and safety of Guipi Mixture combined with metoprolol for treating PVCs associated with heart-spleen deficiency syndrome.

  • 2

    This is a randomized, double-blind, placebo-controlled trial involving 200 subjects across 18 centers in China.

  • 3

    The primary outcome is the absolute change in 24-hour PVC count from baseline to week 8, measured by ambulatory ECG.

  • 4

    Secondary outcomes include responder rate, quality of life, sleep quality, TCM syndrome score, and ECG indicators.

  • 5

    Adverse events will be recorded throughout the 12-week trial, which includes a 2-week screening and 2-week run-in period.

Original Source(s)

Effectiveness and safety of Guipi Mixture for the treatment of premature ventricular contractions (heart-spleen deficiency syndrome): study protocol for a randomized, double-blind, placebo-controlled, multicentre trial

  • by Yonghao Li, Yutong Wang, Ruikang Liu, Xuanchun Huang, Shiyi Tao, FuYuan Zhang, Jun Li, JingRun Cui

  • June 11, 2026

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