Association of therapeutic plasma exchange with functional outcomes in selected neurological disorders: a retrospective cohort study from a single tertiary center in Saudi Arabia - Takeaways - MDSpire

Impact of Therapeutic Plasma Exchange on Functional Outcomes in Specific Neurological Disorders: A Retrospective Cohort Analysis from a Tertiary Center in Saudi Arabia

  • By

  • Fatemah I. Ammar

  • Esraa Aljahdali

  • Amal Alshrif

  • Asmaa Alshareef

  • Dania Faidah

  • Mohammed Almohammadi

  • Seraj Makkawi

  • July 21, 2026

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  • 1

    This study analyzed 133 patients with various neurological disorders who underwent therapeutic plasma exchange (TPE) at NGHA in Jeddah, Saudi Arabia.

  • 2

    Significant improvements in functional outcomes were observed in patients with multiple sclerosis, myasthenia gravis, and Guillain-Barré syndrome following TPE.

  • 3

    TPE was also associated with improved outcomes in neuromyelitis optica spectrum disorder, chronic inflammatory demyelinating polyneuropathy, and autoimmune encephalitis.

  • 4

    Overall mortality among patients was 6.8%, with no deaths directly related to TPE, and comorbidities were common among those with poorer outcomes.

  • 5

    The study's retrospective design limits causal inferences, highlighting the need for further prospective studies to evaluate TPE's role in neurological disorders.

Original Source(s)

Association of therapeutic plasma exchange with functional outcomes in selected neurological disorders: a retrospective cohort study from a single tertiary center in Saudi Arabia

  • by Fatemah I. Ammar, Esraa Aljahdali, Amal Alshrif, Asmaa Alshareef, Dania Faidah, Mohammed Almohammadi, Seraj Makkawi

  • July 21, 2026

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