Prognostic impact of lymphocyte kinetics and immune composition during bispecific antibody therapy in relapsed/refractory multiple myeloma - Takeaways - MDSpire
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Influence of Lymphocyte Dynamics and Immune Profile on Outcomes of Bispecific Antibody Treatment in Relapsed/Refractory Multiple Myeloma

  • By

  • Mansi R. Shah

  • Aishee Bag

  • Asis Shrestha

  • Yetunde Ogunsesan

  • Anup Trikannad

  • Sruthi Vellanki

  • Sanjay Muttineni

  • Hira Cheema

  • Syed Naqvi

  • Sasya Dronavalli

  • Samer Al Hadidi

  • Sharmilan Thanendrarjan

  • Maurizio Zangari

  • Frits van Rhee

  • Aniko Szabo

  • Rajshekar Chakraborty

  • Meera Mohan

  • Carolina Schinke

  • August 22, 2026

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  • 1

    Bispecific antibodies targeting BCMA or GPRC5D show overall response rates of 70% in relapsed/refractory multiple myeloma.

  • 2

    Baseline absolute lymphocyte count (ALC) and lymphocyte subset composition may reflect immune competence affecting bsAb treatment response.

  • 3

    Patients with high-risk cytogenetic abnormalities had lower response rates, while prior autologous stem cell transplant status influenced outcomes.

  • 4

    Lymphocyte kinetics showed a significant initial drop in ALC after bsAb initiation, with responders demonstrating faster recovery.

  • 5

    Exploratory analyses indicated that Day 30 lymphocyte subset measures could predict progression-free survival and overall survival.

Original Source(s)

Prognostic impact of lymphocyte kinetics and immune composition during bispecific antibody therapy in relapsed/refractory multiple myeloma

  • by Mansi R. Shah, Aishee Bag, Asis Shrestha, Yetunde Ogunsesan, Anup Trikannad, Sruthi Vellanki, Sanjay Muttineni, Hira Cheema, Syed Naqvi, Sasya Dronavalli, Samer Al Hadidi, Sharmilan Thanendrarjan, Maurizio Zangari, Frits van Rhee, Aniko Szabo, Rajshekar Chakraborty, Meera Mohan, Carolina Schinke

  • August 22, 2026

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