Case Study: Timely Surgical Treatment of Epilepsy Associated with Mild MOGHE: Clinical Outcomes and Effectiveness

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MOGHE is a newly identified histopathological entity linked to drug-resistant epilepsy, often presenting as epileptic spasms in early childhood.
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Early surgical intervention for MOGHE-associated epilepsy may prevent neurodevelopmental regression and improve long-term outcomes.
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Conventional diagnostic methods struggle to identify the epileptogenic zone in MOGHE, complicating treatment decisions.
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This case study highlights the importance of timely surgical treatment prior to meeting traditional drug-resistant epilepsy criteria.
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Active early surgical treatment is recommended for children with MOGHE to mitigate irreversible neurological damage.

Frontiers In Pediatrics

by Yaning Sun, Liuyin Chen, Mei Jin, Fan Yang, Yakun Du, Jiangshun Fang, Baoguang Li, Zhixuan Sun, Lingyan Wang, Zhenghai Cheng, Zhiguo Yang, Yi Qu
April 21, 2026

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