Macrophage reprogramming through scavenger receptor-guided and cathepsin B-triggered nanodelivery: from intracellular mechanisms to translational applications - Takeaways - MDSpire

Macrophage reprogramming through scavenger receptor-guided and cathepsin B-triggered nanodelivery: from intracellular mechanisms to translational applications

  • By

  • Yang Huang

  • Le Cai

  • Xu Yan

  • Kaiyi Tong

  • Fei Li

  • July 10, 2026

  • 0 min

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  • 1

    Macrophages exhibit significant plasticity and can adopt various functional states influenced by environmental signals.

  • 2

    Pathological macrophages in cancer and atherosclerosis contribute to immune suppression and therapeutic resistance.

  • 3

    Nanomedicine offers strategies for targeted modulation of macrophage behavior through receptor-mediated delivery and controlled release.

  • 4

    Scavenger receptors are enriched in pathological macrophages and play roles in lipid metabolism and inflammatory signaling.

  • 5

    Cathepsin B serves as an endogenous trigger for nanocarrier disassembly, enhancing targeted drug release in macrophage-rich environments.

Original Source(s)

Macrophage reprogramming through scavenger receptor-guided and cathepsin B-triggered nanodelivery: from intracellular mechanisms to translational applications

  • by Yang Huang, Le Cai, Xu Yan, Kaiyi Tong, Fei Li

  • July 10, 2026

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