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1
Elderly-onset rheumatoid arthritis (EORA) is associated with more refractory disease activity and higher comorbidity compared to younger-onset RA.
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2
The gut-joint axis, involving immunosenescence, inflammaging, and gut microbiota dysbiosis, plays a significant role in the pathogenesis of EORA.
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3
Immunosenescence in EORA is characterized by T cell exhaustion, reduced naïve T cells, and increased senescent T cells, impacting disease progression.
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4
Inflammaging contributes to a chronic inflammatory state in EORA, characterized by elevated levels of pro-inflammatory mediators.
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5
Therapeutic strategies targeting gut microbiota, including dietary modifications and fecal microbiota transplantation, show potential for managing EORA.
