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1
Alzheimer's disease is a complex neurodegenerative disorder characterized by amyloid-β accumulation, tau pathology, and chronic neuroinflammation.
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2
Physical exercise has been shown to positively influence several processes related to Alzheimer's disease, including cognition and synaptic plasticity.
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3
Extracellular vesicles (EVs) serve as a mechanism for delivering multiple signals and protecting labile cargo, reflecting the state of the releasing cell.
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Exercise-induced skeletal muscle-derived EVs can be taken up by microglia, contributing to amyloid plaque clearance and cognitive improvement in Alzheimer's models.
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The review proposes a framework where exercise-conditioned EVs link peripheral adaptations to Alzheimer's pathology, potentially serving as biomarkers and therapeutic platforms.
