Immune activation induced by FOLR2+ decidual macrophage deficiency impairs decidualization and angiogenesis in spontaneous abortion - Takeaways - MDSpire

Immune activation induced by FOLR2+ decidual macrophage deficiency impairs decidualization and angiogenesis in spontaneous abortion

  • By

  • Si-Man Chen

  • Meng-Ying Li

  • Yi-Xing Yang

  • Nan Liu

  • Xiao-Yan Cao

  • Hong-Bo Zhao

  • Xiao-Yong Zhu

  • Ming-Qing Li

  • Feng Xie

  • June 23, 2026

  • 0 min

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  • 1

    FOLR2+ macrophages are a distinct subset in the decidua with an M2-like immunoregulatory phenotype crucial for pregnancy maintenance.

  • 2

    In recurrent spontaneous abortion (RSA), FOLR2 expression and the proportion of FOLR2+ macrophages are significantly reduced.

  • 3

    Reduced FOLR2+ macrophages in RSA are associated with increased inflammatory signaling and impaired angiogenesis.

  • 4

    FOLR2 overexpression enhances immunoregulatory and pro-angiogenic properties in macrophages, while silencing promotes inflammation.

  • 5

    The interaction between decidual stromal cells and FOLR2+ macrophages supports decidualization and pregnancy maintenance.

Original Source(s)

Immune activation induced by FOLR2+ decidual macrophage deficiency impairs decidualization and angiogenesis in spontaneous abortion

  • by Si-Man Chen, Meng-Ying Li, Yi-Xing Yang, Nan Liu, Xiao-Yan Cao, Hong-Bo Zhao, Xiao-Yong Zhu, Ming-Qing Li, Feng Xie

  • June 23, 2026

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