Controlled Human Infection of Healthy Adults With Lyophilized Neisseria lactamica Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali - Takeaways - MDSpire

Controlled Human Infection of Healthy Adults With Lyophilized Neisseria lactamica Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali

  • By

  • D F Gbesemete

  • F Haidara

  • J R Laver

  • M Ibrahim

  • J MacLennan

  • A P Dale

  • A R Gorringe

  • Y Traore

  • F Diallo

  • H Badji

  • A Traore

  • U Onwuchekwa

  • E Jones

  • C Webb

  • J Guy

  • A A Theodosiou

  • S N Faust

  • S O Sow

  • R S Heyderman

  • M D Tapia

  • R C Read

  • January 7, 2026

  • 0 min

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  • 1

    Lyophilized Neisseria lactamica (LyoNlac) was safely administered intranasally to healthy adults in the UK and Mali, showing no significant safety concerns.

  • 2

    In the UK, a dose of 105 CFU of LyoNlac achieved 100% colonization, while in Mali, 107 CFU resulted in a 65% colonization rate.

  • 3

    Colonized participants exhibited significant increases in Nlac- and Nmen-specific IgG levels, indicating an immune response post-inoculation.

  • 4

    The study suggests that LyoNlac could potentially reduce Neisseria meningitidis carriage and transmission in sub-Saharan Africa.

  • 5

    Future clinical trials are warranted to evaluate the effectiveness of LyoNlac in preventing meningococcal outbreaks in the meningitis belt.

Original Source(s)

Controlled Human Infection of Healthy Adults With Lyophilized Neisseria lactamica Induces Asymptomatic, Immunogenic Nasopharyngeal Carriage in the United Kingdom and Mali

  • by D F Gbesemete, F Haidara, J R Laver, M Ibrahim, J MacLennan, A P Dale, A R Gorringe, Y Traore, F Diallo, H Badji, A Traore, U Onwuchekwa, E Jones, C Webb, J Guy, A A Theodosiou, S N Faust, S O Sow, R S Heyderman, M D Tapia, R C Read

  • January 7, 2026

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