Determinants of exercise capacity in heart failure with preserved ejection fraction: central hemodynamics, ventilatory efficiency, and peripheral muscle oxygen utilization and function - Takeaways - MDSpire

Determinants of exercise capacity in heart failure with preserved ejection fraction: central hemodynamics, ventilatory efficiency, and peripheral muscle oxygen utilization and function

  • By

  • Raphael Schoch

  • Julia Maria Kröpfl

  • Benedikt Andreas Gasser

  • Denis Infanger

  • Henner Hanssen

  • Rupprecht Wick

  • Luisa Prechtl

  • Thomas Dieterle

  • Arno Schmidt-Trucksäss

  • July 15, 2026

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  • 1

    Exercise intolerance in HFpEF is characterized by reduced peak oxygen uptake (V˙O2peak) due to impairments in central hemodynamics and peripheral factors.

  • 2

    In a study of 46 patients, leg power was strongly associated with relative V˙O2peak, while leg fat-free mass correlated with absolute V˙O2peak.

  • 3

    Stroke volume and heart rate had smaller associations with exercise capacity, while muscle oxygen saturation and ventilatory efficiency showed trivial associations.

  • 4

    Peripheral muscle function is more strongly linked to exercise capacity in HFpEF than central hemodynamics or ventilatory efficiency.

  • 5

    The interplay of central and peripheral factors is essential to understand exercise limitations in patients with HFpEF.

Original Source(s)

Determinants of exercise capacity in heart failure with preserved ejection fraction: central hemodynamics, ventilatory efficiency, and peripheral muscle oxygen utilization and function

  • by Raphael Schoch, Julia Maria Kröpfl, Benedikt Andreas Gasser, Denis Infanger, Henner Hanssen, Rupprecht Wick, Luisa Prechtl, Thomas Dieterle, Arno Schmidt-Trucksäss

  • July 15, 2026

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