Dynamic activation of lytic cell death-related programs identifies CD14 as a candidate hub gene associated with secondary injury after spinal cord injury - Takeaways - MDSpire

Dynamic activation of lytic cell death-related programs identifies CD14 as a candidate hub gene associated with secondary injury after spinal cord injury

  • By

  • Shenglong Wang

  • Ruoxiang Mei

  • Wenting Xu

  • Xiaochen Su

  • Menghao Teng

  • Xiaoxiao Lou

  • Chen Zhang

  • Shenghua Guo

  • Yingang Zhang

  • July 6, 2026

  • 0 min

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  • 1

    Secondary spinal cord injury involves persistent inflammation, oxidative stress, and multiple forms of programmed cell death.

  • 2

    Pyroptosis, necroptosis, and ferroptosis-related transcriptional activities increase after spinal cord injury.

  • 3

    CD14 was identified as a candidate hub gene linked to lytic cell death and myeloid inflammatory activation.

  • 4

    Lytic cell death-related programs are dynamically activated after spinal cord injury and are associated with immune-inflammatory responses.

  • 5

    Further functional studies are required to determine the role of CD14 in modulating lytic cell death pathways after spinal cord injury.

Original Source(s)

Dynamic activation of lytic cell death-related programs identifies CD14 as a candidate hub gene associated with secondary injury after spinal cord injury

  • by Shenglong Wang, Ruoxiang Mei, Wenting Xu, Xiaochen Su, Menghao Teng, Xiaoxiao Lou, Chen Zhang, Shenghua Guo, Yingang Zhang

  • July 6, 2026

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