Mitochondrial dysfunction in EEG: high-beta specific metabolic/oxidative coupling with lactate in mania-predominant polarity - Takeaways - MDSpire

Mitochondrial dysfunction in EEG: high-beta specific metabolic/oxidative coupling with lactate in mania-predominant polarity

  • By

  • Sermin Kesebir

  • Rüştü Murat Demirer

  • April 20, 2026

  • 0 min

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  • 1

    This study investigates the correlation between EEG-derived metrics and lactate levels in bipolar disorder with mania-predominant polarity.

  • 2

    Entropy-doubling is introduced as a novel analytical tool for EEG, revealing complex information structures not captured by traditional methods.

  • 3

    Lactate is recognized as a significant metabolic marker, indicating mitochondrial dysfunction and serving as an alternative energy source for neurons.

  • 4

    The research aims to establish a quantitative biomarker framework linking electrophysiological dynamics with metabolic processes in psychiatric disorders.

  • 5

    Findings suggest that high-beta amplitude entropy correlates strongly with lactate levels, highlighting potential metabolic coupling in bipolar disorder.

Original Source(s)

Mitochondrial dysfunction in EEG: high-beta specific metabolic/oxidative coupling with lactate in mania-predominant polarity

  • by Sermin Kesebir, Rüştü Murat Demirer

  • April 20, 2026

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