Mechanistic study of ARHGAP27 promoting the progression of aortic dissection by regulating the RhoA/ROCK/YAP pathway - Takeaways - MDSpire

Mechanistic study of ARHGAP27 promoting the progression of aortic dissection by regulating the RhoA/ROCK/YAP pathway

  • By

  • Zijie Wang

  • Jing Tao

  • Yining Yang

  • July 10, 2026

  • 0 min

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  • 1

    ARHGAP27 is significantly upregulated in aortic dissection (AD) tissues and is linked to the progression of this cardiovascular disease.

  • 2

    In vitro studies show that overexpression of ARHGAP27 promotes survival, migration, and invasion of vascular smooth muscle cells (VSMCs).

  • 3

    ARHGAP27 influences the expression of synthetic phenotypic proteins MMP2 and MMP9 while inhibiting contraction phenotypes α-SMA and SM22α.

  • 4

    The RhoA/ROCK/YAP signaling pathway is affected by ARHGAP27, with PDGF-BB downregulating RhoA and ROCK1/2 while upregulating YAP phosphorylation.

  • 5

    Knockdown of ARHGAP27 results in opposite effects, indicating its critical role in the phenotypic switching of VSMCs during AD progression.

Original Source(s)

Mechanistic study of ARHGAP27 promoting the progression of aortic dissection by regulating the RhoA/ROCK/YAP pathway

  • by Zijie Wang, Jing Tao, Yining Yang

  • July 10, 2026

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