Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study - Takeaways - MDSpire

Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study

  • By

  • Yuan Gao

  • Yiwei Xu

  • Chuxin Lyu

  • Yuhan Ding

  • Siyuan Yin

  • Ruijie Shi

  • Jiemei Zhou

  • Haowen Zhang

  • Xiaohu Chen

  • June 18, 2026

  • 0 min

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  • 1

    Elevated cholesterol, high-density lipoprotein, and glucose (CHG) index is linked to increased cardiovascular rehospitalization risk in chronic coronary syndromes with anxiety.

  • 2

    Patients in the highest CHG quartile exhibited significantly lower heart rate variability (HRV_z) compared to those in the lowest quartile.

  • 3

    Each 1-unit increase in CHG was associated with a higher risk of 1-year cardiovascular rehospitalization, with an odds ratio of 3.253.

  • 4

    Exploratory analyses indicated that higher HRV_z correlates with a lower risk of rehospitalization in patients with chronic coronary syndromes.

  • 5

    The study suggests that CHG and HRV_z may provide complementary information for assessing cardiovascular risk in patients with CCS and anxiety.

Original Source(s)

Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study

  • by Yuan Gao, Yiwei Xu, Chuxin Lyu, Yuhan Ding, Siyuan Yin, Ruijie Shi, Jiemei Zhou, Haowen Zhang, Xiaohu Chen

  • June 18, 2026

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