Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study - Takeaways - MDSpire
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Preoperative Depletion of Gut Microbiota and Metabolomic Profiles as Predictors of Postoperative Pneumonia in Patients Undergoing Surgery for Intracranial Lesions: A Multi-Omics Prospective Study

  • By

  • Juan Chen

  • Zhiyu Li

  • Yewen Zhan

  • Qianqian Tan

  • Jin Li

  • Hong Pu

  • June 16, 2026

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  • 1

    Postoperative pneumonia (POP) is a significant risk for patients with intracranial lesions due to surgical trauma and impaired immune response.

  • 2

    Preoperative depletion of the gut microbiota, particularly Roseburia, is linked to increased susceptibility to POP.

  • 3

    Metabolomic analysis revealed a preoperative metabolic deficiency in patients who developed POP, affecting fructose and mannose metabolism.

  • 4

    A predictive model based on preoperative metabolic signatures achieved an AUC of 1.0 for identifying patients at risk for POP.

  • 5

    Monitoring gut microbiota and metabolic profiles preoperatively can enhance risk stratification and inform early interventions for POP.

Original Source(s)

Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study

  • by Juan Chen, Zhiyu Li, Yewen Zhan, Qianqian Tan, Jin Li, Hong Pu

  • June 16, 2026

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