Case Report: Right−sided vagus nerve stimulation for treatment−resistant affective disorders with complex cardiac comorbidity - Takeaways - MDSpire

Case Report: Right−sided vagus nerve stimulation for treatment−resistant affective disorders with complex cardiac comorbidity

  • By

  • Christiane Licht

  • Michael Landgrebe

  • Tom Pieper

  • March 19, 2026

  • 0 min

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  • 1

    Right-sided vagus nerve stimulation (VNS) can be a viable treatment for patients with treatment-resistant mood disorders and cardiac complications.

  • 2

    In a case series, three patients showed significant mood stabilization within 12 months after right-sided VNS implantation.

  • 3

    Hospital admission rates decreased markedly, and maintenance electroconvulsive therapy was reduced or discontinued in two patients.

  • 4

    No serious cardiac adverse events were observed during right-sided VNS, challenging the belief that it poses greater cardiac risks.

  • 5

    The findings support further evaluation of right-sided VNS in psychiatric practice, emphasizing the need for multidisciplinary coordination.

Original Source(s)

Case Report: Right−sided vagus nerve stimulation for treatment−resistant affective disorders with complex cardiac comorbidity

  • by Christiane Licht, Michael Landgrebe, Tom Pieper

  • March 19, 2026

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