Mapping Molecular Discordance in the Brain
Single-cell proteomics reveals cell-type-specific regulation invisible to RNA-based methods
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A single-cell proteomics study mapped protein-level differences in the developing human brain, revealing discordance with RNA expression.
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Researchers quantified hundreds of proteins from individual prenatal brain cells using a label-free mass spectrometry workflow.
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The study profiled over 1,500 brain-derived cells, identifying major neural and non-neural populations during development.
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Protein abundance was found to be more cell-type-specific than mRNA levels, highlighting the role of post-transcriptional regulation.
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The findings suggest that single-cell proteomics could clarify the impact of genetic risk on neurodevelopmental disorders.
