Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study - Takeaways - MDSpire

Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study

  • By

  • Kaitlin J Mayne

  • Heather Walker

  • Benjamin M P Elyan

  • Patrick B Mark

  • Paul Welsh

  • Ninian N Lang

  • Naveed A Sattar

  • Jill P Pell

  • Frederick K Ho

  • Jennifer S Lees

  • August 19, 2025

  • 0 min

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  • 1

    CKM syndrome reflects the interrelatedness of metabolic risk factors, diabetes, cardiovascular disease, and chronic kidney disease.

  • 2

    In the UK Biobank cohort, CKM Stages 2-4 were associated with increased mortality in both males and females.

  • 3

    Stage 1 CKM was not significantly linked to increased mortality risk compared to Stage 0, despite higher obesity metrics.

  • 4

    Mortality risk increased with CKM stage, with larger absolute risk increases observed in males than females.

  • 5

    The study highlights limitations in CKM syndrome classification and its potential utility in routine clinical settings.

Original Source(s)

Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study

  • by Kaitlin J Mayne, Heather Walker, Benjamin M P Elyan, Patrick B Mark, Paul Welsh, Ninian N Lang, Naveed A Sattar, Jill P Pell, Frederick K Ho, Jennifer S Lees

  • August 19, 2025

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