A Molecular Atlas of the Alzheimer’s Brain
Label-free Raman imaging reveals molecular heterogeneity across Alzheimer’s-affected brain regions
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Researchers created the first complete, label-free molecular atlas of the Alzheimer's brain using hyperspectral Raman imaging.
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The study revealed region-specific chemical changes in the brain that extend beyond amyloid plaques, challenging conventional imaging methods.
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Machine-learning analysis was combined with imaging to identify molecularly distinct brain areas and quantify disease-associated chemistry.
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Significant regional heterogeneity in Alzheimer’s-related molecular changes was found, particularly in memory-associated areas like the hippocampus.
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The findings indicate broader disruptions in brain structure and energy balance in Alzheimer's, beyond just protein aggregation.
