The Role of Gut Microbiome and Its Metabolites in Characterizing the Phenotypic Spectrum of Multiple Sclerosis

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Multiple sclerosis (MS) is influenced by environmental factors, including alterations in the gut microbiome that affect disease risk and progression.
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Microbial metabolites play a crucial role in modulating immune responses and neuroinflammation in MS, impacting T-cell differentiation and glial activation.
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Longitudinal studies indicate that changes in microbial metabolic profiles correlate with worsening disability in MS patients.
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Therapeutic strategies targeting microbial metabolism may offer new avenues for treatment in MS by reshaping gut-immune-brain interactions.
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Understanding the relationship between gut microbiota composition and MS is essential for developing microbiome-informed precision therapies.

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