Gut microbiota and gut-derived metabolites in defining multiple sclerosis phenotypic continuum

1

Multiple sclerosis (MS) is influenced by environmental factors, including alterations in the gut microbiome that affect disease risk and progression.
2

Microbial metabolites play a crucial role in modulating immune responses and neuroinflammation in MS, impacting T-cell differentiation and glial activation.
3

Longitudinal studies indicate that changes in microbial metabolic profiles correlate with worsening disability in MS patients.
4

Therapeutic strategies targeting microbial metabolism may offer new avenues for treatment in MS by reshaping gut-immune-brain interactions.
5

Understanding the relationship between gut microbiota composition and MS is essential for developing microbiome-informed precision therapies.

1