Sepsis and septic shock case identification from electronic health records: an open-source workflow and comparison of cohorts by criteria - Takeaways - MDSpire

Sepsis and septic shock case identification from electronic health records: an open-source workflow and comparison of cohorts by criteria

  • By

  • Seth R. Bauer

  • Lyla Mourany

  • Paul R. Gunsalus

  • Alex Milinovich

  • Sandra L. Kane-Gill

  • Xiaofeng Wang

  • Yasir Tarabichi

  • Vidula Vachharajani

  • Jarrod E. Dalton

  • December 12, 2025

  • 0 min

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  • 1

    The study aims to derive sepsis and septic shock cases from electronic health records using open-source programming code for reproducibility.

  • 2

    Multiple clinical criteria exist for identifying sepsis, including CDC ASE and Sepsis-3, but their diagnostic performance varies significantly.

  • 3

    A comprehensive data workflow was developed for sepsis case identification, involving data extraction, transformation, and application of criteria.

  • 4

    The research utilized patient encounters from 2012 to 2024 across 25 Cleveland Clinic emergency departments and hospitals.

  • 5

    All programming code and methodological details for the sepsis identification workflow are publicly available on GitHub to promote transparency.

Original Source(s)

Sepsis and septic shock case identification from electronic health records: an open-source workflow and comparison of cohorts by criteria

  • by Seth R. Bauer, Lyla Mourany, Paul R. Gunsalus, Alex Milinovich, Sandra L. Kane-Gill, Xiaofeng Wang, Yasir Tarabichi, Vidula Vachharajani, Jarrod E. Dalton

  • December 12, 2025

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