Manic episode following lurasidone initiation in bipolar I disorder: a case report - Takeaways - MDSpire

Manic episode following lurasidone initiation in bipolar I disorder: a case report

  • By

  • Nasser M. Alzain

  • Feras A. Al-Awad

  • Saleh A. Alzahrani

  • Fahad M. Almsned

  • June 9, 2026

  • 0 min

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  • 1

    Lurasidone is a second-generation antipsychotic effective for bipolar depression but may induce manic episodes in susceptible patients.

  • 2

    A 43-year-old man with bipolar I disorder developed acute mania after lurasidone titration, highlighting the need for careful monitoring.

  • 3

    The patient exhibited symptoms of mania, including elevated mood, irritability, and significantly reduced sleep after one week of treatment.

  • 4

    Immediate discontinuation of lurasidone and adjustment of sodium valproate led to a rapid reduction in manic symptoms and stabilization.

  • 5

    This case underscores the importance of monitoring for manic symptoms during lurasidone treatment in patients with bipolar I disorder.

Original Source(s)

Manic episode following lurasidone initiation in bipolar I disorder: a case report

  • by Nasser M. Alzain, Feras A. Al-Awad, Saleh A. Alzahrani, Fahad M. Almsned

  • June 9, 2026

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