Acute Mania Induced by Lurasidone Treatment in a Patient with Bipolar I Disorder: A Case Study

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Lurasidone is a second-generation antipsychotic effective for bipolar depression but may induce manic episodes in susceptible patients.
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A 43-year-old man with bipolar I disorder developed acute mania after lurasidone titration, highlighting the need for careful monitoring.
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The patient exhibited symptoms of mania, including elevated mood, irritability, and significantly reduced sleep after one week of treatment.
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Immediate discontinuation of lurasidone and adjustment of sodium valproate led to a rapid reduction in manic symptoms and stabilization.
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This case underscores the importance of monitoring for manic symptoms during lurasidone treatment in patients with bipolar I disorder.

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