The Evolution of Pediatric AKI—Lessons From the Past, Priorities for the Future - Takeaways - MDSpire
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Advancements in Understanding Pediatric Acute Kidney Injury: Insights from History and Future Directions

  • By

  • Laura Rangel Rodriguez

  • David T. Selewski

  • September 22, 2026

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  • 1

    Acute kidney injury (AKI) has become a significant concern in pediatric care, previously overlooked as a complication.

  • 2

    The AWARE and AWAKEN studies documented high AKI incidence in pediatric populations, linking it to morbidity, mortality, and prolonged hospitalization.

  • 3

    From 1997 to 2022, annual AKI cases rose from 6,318 to 63,923, while dialysis-requiring AKI cases increased from 981 to 2,075.

  • 4

    Mortality rates for hospitalizations complicated by AKI decreased significantly from 1,814 to 643 per 10,000 between 2003 and 2022.

  • 5

    Survivors of AKI face increased risks of chronic kidney disease and cardiovascular complications, necessitating long-term follow-up and care.

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