A Closer Look at Vascular Cell States in Marfan Syndrome

Single-cell proteomics identifies Marfan-enriched smooth muscle states and endothelial transition signatures

1

A single-cell proteomics workflow revealed distinct vascular cell states in Marfan syndrome, highlighting aneurysm-related changes in the aortic wall.
2

Researchers analyzed nearly 5,000 cells from aortic roots of wild-type and Fbn1C1041G/+ mice, identifying major aortic cell types.
3

The study identified 16 cell groups, including seven smooth muscle cell subtypes, revealing heterogeneity not captured by bulk analysis.
4

Altered smooth muscle cell states were more prevalent in Marfan tissue, with specific markers indicating shifts during aneurysm development.
5

Integration of proteomic and transcriptomic data identified additional Marfan-associated cell states, emphasizing the need for functional studies.

1