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1
Inflammatory bowel disease (IBD) features mucus and epithelial barrier dysfunction, with regulatory mechanisms remaining inconsistent across studies.
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2
A meta-analysis of 26 human colonic transcriptomic datasets identified 3,129 differentially expressed genes in Crohn's disease and 3,729 in ulcerative colitis.
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3
Key pathways upregulated in IBD include goblet-cell differentiation, mucin transcription, and endoplasmic reticulum quality control.
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4
Mucus barrier dysfunction in IBD reflects inflammatory remodeling rather than primary secretory collapse, sharing ER-stress and microbial response signatures.
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5
Integrating human and murine datasets reveals candidate pathways that may stabilize mucin folding and preserve host-microbe spatial segregation in intestinal disease.
