Association between metabolic syndrome components and the risk of malignant neoplasms of the brain: a nationwide cohort study

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A nationwide cohort study analyzed 3,976,961 individuals to assess the link between metabolic syndrome components and brain malignancy risk.
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Participants with three or more metabolic syndrome components showed a statistically significant increased risk of malignant neoplasms of the brain.
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Elevated triglycerides were identified as having the strongest independent association with brain malignancy risk among metabolic syndrome components.
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The study's findings suggest that managing metabolic health, particularly lipid levels, may aid in brain tumor risk assessment.
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Further research is needed to validate these findings and explore the mechanistic links between metabolic syndrome and brain tumors.

Frontiers In Oncology

by Taek Min Nam, Min-ho Kim, Na Rae Yang, Yongjae Cho, Sung-Kyun Hwang, Dosang Cho, Young Goo Kim
June 18, 2026

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