Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease - Takeaways - MDSpire

Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease

  • By

  • Haitao Chu

  • Xin Song

  • Chang Liu

  • Tianjiao Ma

  • Wanlin Cui

  • June 9, 2026

  • 0 min

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  • 1

    Bile salt hydrolase (BSH) is a microbial enzyme that plays a crucial role in bile acid metabolism and host-microbiota interactions.

  • 2

    BSH activity influences host energy metabolism, immune homeostasis, and intestinal barrier integrity through bile acid signaling pathways.

  • 3

    Dysregulation of BSH is linked to major digestive diseases, including metabolic dysfunction-associated steatotic liver disease, inflammatory bowel disease, and colorectal cancer.

  • 4

    Emerging strategies targeting BSH, such as strain-specific probiotics and dietary interventions, offer potential therapeutic avenues for digestive diseases.

  • 5

    BSH functions as a regulatory node that connects microbial activity to host metabolism and immunity, emphasizing its importance in maintaining digestive homeostasis.

Original Source(s)

Gut microbial bile salt hydrolase as a metabolic gatekeeper in digestive homeostasis and disease

  • by Haitao Chu, Xin Song, Chang Liu, Tianjiao Ma, Wanlin Cui

  • June 9, 2026

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