Label-Free Multiphoton Microscopy for intraoperative Identification of Glioma Features and Tumor Heterogeneity - Takeaways - MDSpire

Label-Free Multiphoton Microscopy for intraoperative Identification of Glioma Features and Tumor Heterogeneity

  • By

  • Duncker, León V.

  • Richter, Sven

  • Galli, Roberta

  • Meinhardt, Matthias

  • Hoffmann, Leon C.

  • Kirsche, Katrin

  • Großer, Lidia

  • Temme, Achim

  • Eyüpoglu, Ilker Y.

  • Uckermann, Ortrud

  • June 22, 2026

  • 0 min

Share

  • 1

    Diffuse gliomas are heterogeneous brain tumors with varying biological behavior and aggressiveness.

  • 2

    Label-free multiphoton imaging was investigated for intraoperative glioma grading using a multimodal approach.

  • 3

    The study included data from 102 glioma patients, covering glioblastoma and astrocytoma of various grades.

  • 4

    CARS, autofluorescence, and SHG imaging revealed specific histological features linked to tumor malignancy.

  • 5

    A numerical score based on imaging features indicated malignancy levels, with the highest scores in WHO grade 4 tumors.

Original Source(s)

Label-Free Multiphoton Microscopy for intraoperative Identification of Glioma Features and Tumor Heterogeneity

  • by Duncker, León V., Richter, Sven , Galli, Roberta , Meinhardt, Matthias , Hoffmann, Leon C., Kirsche, Katrin , Großer, Lidia , Temme, Achim , Eyüpoglu, Ilker Y., Uckermann, Ortrud

  • June 22, 2026

Related Content

Case Report: Extranodal marginal zone B-cell lymphoma in the lateral ventricle: literature review

Editorial: Innovative strategies in overcoming glioblastoma: advancements in treatment and research

Venous Thromboembolism and Secondary Outcomes of Bleeding and Mortality in Patients with Gliomas: A Multicenter Cohort Study