Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis - Takeaways - MDSpire

Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis

  • By

  • Zhoubo Yu

  • Jing Yang

  • Junhao Zhang

  • Yuxin He

  • Ming Liu

  • Pengfei Ren

  • Jiannan Meng

  • Rui Wang

  • June 19, 2026

  • 0 min

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  • 1

    The study evaluates the transdermal absorption of miRNA55 delivered via microneedles at specific acupoints in a rabbit model of rheumatoid arthritis.

  • 2

    miRNA55 concentrations were highest in the joint cavity fluid of rabbits treated at the classical acupoint ST36 compared to GB34 and non-acupoint areas.

  • 3

    PK/PD modeling indicated higher efficacy values for ST36 across inflammatory cytokines IL-1β, TNF-α, and IL-6 compared to other groups.

  • 4

    Western blot analysis showed lower expression levels of inflammatory proteins in the ST36 group, indicating reduced inflammation.

  • 5

    Histopathological evaluation revealed less synovial erosion and lymphokine infiltration in the ST36 group compared to GB34 and non-acupoint groups.

Original Source(s)

Experimental verification and PK/PD modeling of selective drug absorption via acupoint administration in rabbit model of rheumatoid arthritis

  • by Zhoubo Yu, Jing Yang, Junhao Zhang, Yuxin He, Ming Liu, Pengfei Ren, Jiannan Meng, Rui Wang

  • June 19, 2026

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