Chronic infections of knee megaprostheses: are “Off-Label” DAIR-Plus or partial two-stage exchange viable options? - Takeaways - MDSpire

Chronic infections of knee megaprostheses: are “Off-Label” DAIR-Plus or partial two-stage exchange viable options?

  • By

  • Davide Stimolo

  • Matteo Innocenti

  • Mattia Carminati

  • Filippo Castrogiovanni

  • Elisabetta Neri

  • Domenico Andrea Campanacci

  • Guido Scoccianti

  • February 19, 2026

  • 0 min

Share

  • 1

    Periprosthetic joint infections in megaprostheses have infection rates of 15 to 40%, complicating surgical treatment and increasing amputation risks.

  • 2

    DAIR-Plus, which retains stems while removing mobile components, may reduce the need for complete implant removal in chronic knee megaprosthetic infections.

  • 3

    The study evaluated DAIR-Plus and partial two-stage exchange in 19 patients with chronic knee megaprosthetic infections over a minimum of two years.

  • 4

    Infection resolution rates and prognostic factors were analyzed to guide treatment decisions between DAIR-Plus and more invasive procedures.

  • 5

    The findings aim to clarify the efficacy of DAIR-Plus and partial two-stage exchange, addressing gaps in existing literature on megaprosthetic PJIs.

Original Source(s)

Chronic infections of knee megaprostheses: are “Off-Label” DAIR-Plus or partial two-stage exchange viable options?

  • by Davide Stimolo, Matteo Innocenti, Mattia Carminati, Filippo Castrogiovanni, Elisabetta Neri, Domenico Andrea Campanacci, Guido Scoccianti

  • February 19, 2026

Related Content

Recurrent dysplasia epiphysealis hemimelica: a case report and review of the literature

Association of perioperative patient characteristics, intraoperative fluid management, and vasopressors with anastomotic leakage after Ivor-Lewis esophagectomy—a single center retrospective cohort

Long-term outcomes of two-stage revision with positive cultures at reimplantation