Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer - Takeaways - MDSpire

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

  • By

  • Janine Kövilein

  • Adam Sorbie

  • Sevana Khaloian

  • Vanessa Küntzel

  • Miriam von Stern

  • Mohamed Ahmed

  • Sebastian Jarosch

  • Marianne Remke

  • Amira Metwaly

  • Elena M Reuss

  • Dirk H Busch

  • Matthieu Allez

  • Katja Steiger

  • Barbara Schraml

  • Olivia I Coleman

  • Dirk Haller

  • July 14, 2025

  • 0 min

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  • 1

    Chronic inflammation in inflammatory bowel disease (IBD) increases the risk of developing colitis-associated cancer (CAC).

  • 2

    IL-10 deficiency in a mouse model significantly enhances tumor susceptibility, leading to colonic adenomas and invasive carcinomas.

  • 3

    The study established a novel murine model to investigate ATF6-mediated tumorigenesis under germ-free and specific pathogen-free conditions.

  • 4

    Microbiota-dependent tumor formation was confirmed by colonizing germ-free mice with minimal biosynthetic consortia and IBD stool.

  • 5

    Increased ATF6 expression during active IBD in patients underscores the relevance of this model to human disease.

Original Source(s)

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

  • by Janine Kövilein, Adam Sorbie, Sevana Khaloian, Vanessa Küntzel, Miriam von Stern, Mohamed Ahmed, Sebastian Jarosch, Marianne Remke, Amira Metwaly, Elena M Reuss, Dirk H Busch, Matthieu Allez, Katja Steiger, Barbara Schraml, Olivia I Coleman, Dirk Haller

  • July 14, 2025

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