Thyroxin displacement from single and combined thyroid hormone binding proteins by various test substances - Takeaways - MDSpire

Thyroxin displacement from single and combined thyroid hormone binding proteins by various test substances

  • By

  • J. Brandt

  • E. Fabian

  • A. Aktalay-Hippchen

  • L. Jedermann

  • R. Landsiedel

  • June 27, 2026

  • 0 min

Share

  • 1

    Thyroid hormones are essential for fetal and neuronal development, energy homeostasis, and thermogenesis.

  • 2

    L-thyroxine (T4) is primarily bound to three proteins: thyroxine binding globulin (TBG), transthyretin (TTR), and human serum albumin (HSA).

  • 3

    Displacement of T4 from TTR by exogenous compounds can lead to increased free T4 levels and potential adverse developmental outcomes.

  • 4

    A thyroid hormone protein binding (THPB) assay was developed to measure the displacement of T4 by various test substances from different binding proteins.

  • 5

    Eight test substances were evaluated for their ability to interfere with T4 binding to human TTR, TBG, and mixtures of THBPs.

Original Source(s)

Thyroxin displacement from single and combined thyroid hormone binding proteins by various test substances

  • by J. Brandt, E. Fabian, A. Aktalay-Hippchen, L. Jedermann, R. Landsiedel

  • June 27, 2026

Related Content

Higher Steroid Exposure Linked to Systemic Adverse Events in CRSwNP

Higher annual oral corticosteroid exposure was associated with greater odds of systemic adverse events, with avascular bone necrosis and pneumonia showing dose-dependent associations with cumulative dose and osteoporosis associated with longer annual exposure duration.

Frequency of autoimmune diseases in children and adolescents with type 1 diabetes mellitus

Quantitative pancreatic MRI in diabetes mellitus: current advances and future directions