Association between the TNF-α-308G/A and TNF-α-238G/A polymorphisms and systemic lupus erythematosus susceptibility: an updated meta-analysis - Takeaways - MDSpire

Association between the TNF-α-308G/A and TNF-α-238G/A polymorphisms and systemic lupus erythematosus susceptibility: an updated meta-analysis

  • By

  • Jiayi Wang

  • Yiwei Zhang

  • Lanfang Wang

  • Peng Huang

  • June 23, 2026

  • 0 min

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  • 1

    The meta-analysis evaluated the association between TNF-α-308G/A and TNF-α-238G/A polymorphisms and systemic lupus erythematosus susceptibility.

  • 2

    Fifty-three studies on TNF-α-308G/A and eighteen on TNF-α-238G/A were included in the analysis.

  • 3

    TNF-α-308G/A polymorphism was linked to increased susceptibility to systemic lupus erythematosus across various populations.

  • 4

    No significant association was found for TNF-α-238G/A polymorphism regarding systemic lupus erythematosus susceptibility.

  • 5

    The study concluded that significant associations may be false positives, as indicated by high BFDP values.

Original Source(s)

Association between the TNF-α-308G/A and TNF-α-238G/A polymorphisms and systemic lupus erythematosus susceptibility: an updated meta-analysis

  • by Jiayi Wang, Yiwei Zhang, Lanfang Wang, Peng Huang

  • June 23, 2026

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