Case Report: Supraorbital keyhole resection of IDH-mutant grade 3 astrocytoma of the medial orbitofrontal region - Takeaways - MDSpire

Case Report: Supraorbital keyhole resection of IDH-mutant grade 3 astrocytoma of the medial orbitofrontal region

  • By

  • Nurali Ashirov

  • David Pochivalov

  • Daniyar Zhamoldin

  • Viktor Aleinikov

  • Berik Zhetpisbayev

  • Aisa Nurpeisov

  • Vladimir Kenzhebayev

  • Serik Akshulakov

  • July 10, 2026

  • 0 min

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  • 1

    A 47-year-old female with IDH-mutant Grade 3 astrocytoma underwent gross total resection via a supraorbital trans-eyebrow craniotomy.

  • 2

    Postoperative MRI confirmed gross total resection without residual tumor, and histopathology showed microvascular proliferation consistent with Grade 3 astrocytoma.

  • 3

    Molecular analysis confirmed the presence of an IDH1 mutation, supporting the diagnosis of astrocytoma, IDH-mutant, WHO Grade 3.

  • 4

    The patient received standard adjuvant radiochemotherapy with temozolomide and demonstrated preserved neurological function postoperatively.

  • 5

    The case highlights the efficacy of the supraorbital keyhole approach in achieving oncologically adequate resection with minimal morbidity.

Original Source(s)

Case Report: Supraorbital keyhole resection of IDH-mutant grade 3 astrocytoma of the medial orbitofrontal region

  • by Nurali Ashirov, David Pochivalov, Daniyar Zhamoldin, Viktor Aleinikov, Berik Zhetpisbayev, Aisa Nurpeisov, Vladimir Kenzhebayev, Serik Akshulakov

  • July 10, 2026

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