Intestinal Microbiota Reduces Stress-Induced Cancer Metastasis via Oleic Acid Breakdown - Takeaways - MDSpire

Intestinal Microbiota Reduces Stress-Induced Cancer Metastasis via Oleic Acid Breakdown

  • By

  • Chen Liu

  • Junli Gong

  • Zhanhao Luo

  • Peng Lai

  • Shuang Guo

  • Dayi Liang

  • Guangyuan Chen

  • Mengze Xing

  • Jing Yu

  • Yanchun Xie

  • Danling Liu

  • Wanyi Zeng

  • Zhen He

  • Ping Lan

  • May 1, 2026

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  • 1

    Chronic psychological stress accelerates cancer metastasis, with gut microbiota and their metabolites influencing tumor behavior.

  • 2

    Bifidobacterium animalis is identified as a stress-sensitive species whose loss promotes colorectal cancer metastasis through oleic acid accumulation.

  • 3

    A novel stress-B. animalis-oleic acid axis is revealed, linking chronic stress to tumor progression via disrupted epithelial guanine metabolism.

  • 4

    Supplementation with B. animalis effectively resists metastasis, highlighting its potential as a therapeutic target in stress-related cancer management.

  • 5

    The study provides foundational insights for microbiota-targeted strategies to prevent metastatic events influenced by chronic stress.

Original Source(s)

Intestinal Microbiota Reduces Stress-Induced Cancer Metastasis via Oleic Acid Breakdown

  • by Chen Liu, Junli Gong, Zhanhao Luo, Peng Lai, Shuang Guo, Dayi Liang, Guangyuan Chen, Mengze Xing, Jing Yu, Yanchun Xie, Danling Liu, Wanyi Zeng, Zhen He, Ping Lan

  • May 1, 2026

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