Comparative Analysis of Unipolar and Bipolar Nanosecond Pulses in Calcium Electrochemotherapy and Immune Activation - Takeaways - MDSpire

Comparative Analysis of Unipolar and Bipolar Nanosecond Pulses in Calcium Electrochemotherapy and Immune Activation

  • By

  • Eivina Radzevičiūtė-Valčiukė

  • Augustinas Želvys

  • Veronika Malyško

  • Eglė Mickevičiūtė-Zinkuvienė

  • Paulina Malakauskaitė

  • Barbora Lekešytė

  • Jovita Gečaitė

  • Auksė Zinkevičienė

  • Vytautas Kašėta

  • Julita Kulbacka

  • Joanna Rossowska

  • Vitalij Novickij

  • April 20, 2026

  • 0 min

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  • 1

    Calcium electrochemotherapy (CaECT) utilizes supraphysiological calcium concentrations to induce cell death, offering an alternative to standard chemotherapy.

  • 2

    This study compares unipolar and bipolar nanosecond pulses for CaECT, highlighting bipolar pulses' potential for better impedance mitigation.

  • 3

    In vivo results showed that bipolar pulses did not trigger the predicted bipolar cancellation phenomenon observed in vitro.

  • 4

    CaECT treatments led to systemic immune changes, including increased memory T-cell populations and reduced regulatory T cells.

  • 5

    Bipolar pulses were associated with significant modulation of lymph-node immune composition compared to unipolar pulses.

Original Source(s)

Comparative Analysis of Unipolar and Bipolar Nanosecond Pulses in Calcium Electrochemotherapy and Immune Activation

  • by Eivina Radzevičiūtė-Valčiukė, Augustinas Želvys, Veronika Malyško, Eglė Mickevičiūtė-Zinkuvienė, Paulina Malakauskaitė, Barbora Lekešytė, Jovita Gečaitė, Auksė Zinkevičienė, Vytautas Kašėta, Julita Kulbacka, Joanna Rossowska, Vitalij Novickij

  • April 20, 2026

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