Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study - Takeaways - MDSpire

Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study

  • By

  • Xiaojing Li

  • Anke Shi

  • Yu Wang

  • Xiaolan Chen

  • Guoqiang Zhang

  • Shengtao Yan

  • May 18, 2026

  • 0 min

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  • 1

    Procalcitonin (PCT) is recommended for guiding antibiotic therapy discontinuation in China, yet real-world adherence is low.

  • 2

    In a study of 195 patients, 52.3% adhered to PCT guidelines, resulting in lower mortality rates compared to non-compliant cases.

  • 3

    Early antibiotic discontinuation within 24 hours was linked to shorter EICU stays and reduced antibiotic exposure without increasing mortality.

  • 4

    Adherence to PCT-guided algorithms was particularly low, highlighting the need for improved compliance in clinical practice.

  • 5

    Further prospective studies are necessary to validate the findings regarding PCT-guided antibiotic management in China.

Original Source(s)

Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study

  • by Xiaojing Li, Anke Shi, Yu Wang, Xiaolan Chen, Guoqiang Zhang, Shengtao Yan

  • May 18, 2026

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