Association of Macrophage Accumulation and Polarization in Patients with Obesity and Diabetes with Diabetic Remission After Bariatric Surgery

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Type 2 Diabetes Mellitus is linked to obesity, characterized by insulin resistance and impaired glucose homeostasis.
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Adipose tissue acts as an active endocrine organ, secreting adipokines that regulate inflammation and insulin sensitivity.
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Macrophage polarization in adipose tissue influences metabolic processes, with M1 macrophages promoting inflammation and insulin resistance.
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Bariatric surgery is effective for diabetic remission in patients with severe obesity and intractable type 2 diabetes.
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The study investigates macrophage distribution in visceral fat as a predictor for diabetic remission post-bariatric surgery.

Obesity Surgery

by Sa-Hong Kim, Ji-Soo Kim, Jaeun Yoo, Kyoungyun Jeong, Jeesun Kim, Yo-Seok Cho, Ji-Hyeon Park, Jaemoon Koh, Seong-Ho Kong, Do-Joong Park, Young-Min Cho, Doo Hyun Chung, Han-Kwang Yang, Hyuk-Joon Lee
December 22, 2025

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