The Many Faces of Tau
Mass spectrometry reveals distinct tau chemistries across Alzheimer’s and related dementias
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Distinct neurodegenerative diseases exhibit specific chemical signatures of tau protein, challenging the uniform approach to tau-related dementia.
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Tau aggregation is a hallmark of over 20 neurodegenerative conditions, including Alzheimer's disease and chronic traumatic encephalopathy.
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Researchers analyzed post-mortem brain tissue from 203 individuals to characterize pathological tau using a quantitative mass-spectrometry workflow.
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The study identified 145 post-translational modifications and 195 cleavage sites, revealing unique patterns for each tauopathy.
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Machine learning models ranked tau modifications by importance, providing a roadmap for diagnostics and therapeutic development.
