Timely Implementation of Guideline-Recommended Medical Therapy in Patients Experiencing Cardiogenic Shock with Impella® Support: A Retrospective Analysis from Two Centers - Takeaways - MDSpire

Timely Implementation of Guideline-Recommended Medical Therapy in Patients Experiencing Cardiogenic Shock with Impella® Support: A Retrospective Analysis from Two Centers

  • By

  • Junichiro Yokawa

  • Tetsuo Nishikawa

  • Masaya Shimojima

  • Miho Nakamura

  • Yuma Amino

  • Koji Sato

  • Yoshinao Koshida

  • Takumi Taniguchi

  • November 19, 2025

  • 0 min

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  • 1

    Guideline-directed medical therapy (GDMT) is crucial for managing heart failure with reduced ejection fraction in ICU settings.

  • 2

    This study aimed to assess the impact of early GDMT initiation on outcomes in patients with cardiogenic shock supported by Impella®.

  • 3

    A simple GDMT score was used to evaluate therapy implementation, with a score of ≥ 5 indicating a favorable prognosis.

  • 4

    The study included adult patients who received Impella® support for cardiogenic shock, excluding those who died in ICU.

  • 5

    Primary outcomes included 6-month all-cause mortality and heart failure readmission, analyzed using Kaplan-Meier methods.

Original Source(s)

Timely Implementation of Guideline-Recommended Medical Therapy in Patients Experiencing Cardiogenic Shock with Impella® Support: A Retrospective Analysis from Two Centers

  • by Junichiro Yokawa, Tetsuo Nishikawa, Masaya Shimojima, Miho Nakamura, Yuma Amino, Koji Sato, Yoshinao Koshida, Takumi Taniguchi

  • November 19, 2025

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