Integrative genomic profiling identifies MLPH as a candidate gene in prostate cancer - Takeaways - MDSpire

Integrative genomic profiling identifies MLPH as a candidate gene in prostate cancer

  • By

  • Runyi Wang

  • Jiayu Wang

  • Zhiyi Zhao

  • Xiaopeng Hu

  • July 10, 2026

  • 0 min

Share

  • 1

    This study integrates multi-omics data to identify candidate susceptibility genes for prostate cancer (PCa).

  • 2

    MLPH was prioritized as a candidate gene associated with PCa through various genetic analyses and expression studies.

  • 3

    The lead variant rs7582964 showed significant association with MLPH expression in prostate cancer tumor tissues.

  • 4

    MLPH expression was found to be upregulated in PCa tissues compared to normal prostate tissues.

  • 5

    Lower MLPH expression correlated with higher preoperative PSA levels and poorer histological differentiation in tumors.

Original Source(s)

Integrative genomic profiling identifies MLPH as a candidate gene in prostate cancer

  • by Runyi Wang, Jiayu Wang, Zhiyi Zhao, Xiaopeng Hu

  • July 10, 2026

Related Content

Context-dependent regulation of IL-6 in exercise and colorectal cancer cachexia

Factors associated with unmet psychological care needs and development of a Neuman systems model-based risk prediction model in patients with hepatocellular carcinoma

Colorectal cancer liver metastases: mechanism and therapy