Case Report: Ovarian dysgerminoma mimicking a sex cord-stromal tumor with hyperandrogenism: diagnostic challenges and molecular insights - Takeaways - MDSpire

Case Report: Ovarian dysgerminoma mimicking a sex cord-stromal tumor with hyperandrogenism: diagnostic challenges and molecular insights

  • By

  • Yuan Wang

  • Xue Hao

  • Jiajun Li

  • Yifan Gao

  • Juan Wang

  • Wenxin Wu

  • Jinfeng Cui

  • May 15, 2026

  • 0 min

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  • 1

    Ovarian dysgerminoma is a rare malignant germ cell tumor that can present with endocrine symptoms, complicating diagnosis.

  • 2

    An 8-year-old girl exhibited hyperandrogenism and a large ovarian mass, initially misdiagnosed as a sex cord-stromal tumor.

  • 3

    Histopathological examination revealed unusual architectural patterns in the dysgerminoma, including pseudoglandular and tubular structures.

  • 4

    Molecular profiling identified KRAS and CDK4 amplifications, indicating a high proliferative index and aggressive tumor behavior.

  • 5

    The patient achieved sustained remission after surgery and chemotherapy, highlighting the importance of accurate diagnosis and integrated approaches.

Original Source(s)

Case Report: Ovarian dysgerminoma mimicking a sex cord-stromal tumor with hyperandrogenism: diagnostic challenges and molecular insights

  • by Yuan Wang, Xue Hao, Jiajun Li, Yifan Gao, Juan Wang, Wenxin Wu, Jinfeng Cui

  • May 15, 2026

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