Surgical resection versus biopsy in the treatment of primary central nervous system lymphoma: a systematic review and meta-analysis

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Primary central nervous system lymphoma (PCNSL) is an aggressive CNS tumor primarily affecting the elderly and those with compromised immune systems.
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High-dose methotrexate-based chemotherapy is the recommended first-line treatment for PCNSL, with a poor overall prognosis and a 5-year survival rate of approximately 28%.
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The role of surgical resection in PCNSL treatment remains unclear, with conflicting studies on its impact on overall survival and progression-free survival.
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This meta-analysis aimed to compare overall survival and progression-free survival between patients undergoing surgical resection and those receiving biopsy alone.
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The study included high-quality articles comparing resection and biopsy, assessing outcomes like survival rates and complications in PCNSL patients.

Journal Of Neuro-Oncology

by Rafał Chojak, Marta Koźba-Gosztyła, Karolina Polańska, Marta Rojek, Aleksandra Chojko, Rafał Bogacz, Natalia Skorupa, Jakub Więcław, Bogdan Czapiga
November 30, 2022

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