Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study - Takeaways - MDSpire

Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study

  • By

  • Yugen Shi

  • Wenjing Yi

  • Xue Feng

  • Qingshan Zhang

  • Shuai Bao

  • Li Sun

  • Suhua Yan

  • Nannan Li

  • Xiaolu Li

  • July 16, 2026

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  • 1

    Suxiao Jiuxin Pill (SJP) is investigated for its potential in treating acute myocardial infarction (AMI) through network pharmacology and Mendelian randomization.

  • 2

    The study identified 44 differentially expressed target genes (DE-TGs) related to SJP, with NAMPT and FOS showing significant upregulation in AMI samples.

  • 3

    Molecular docking revealed that NAMPT binds to oleic acid and FOS binds to pentadecanol, supporting their roles in SJP's therapeutic effects.

  • 4

    Echocardiographic assessments indicated that SJP improved cardiac function and reduced inflammatory responses in a rat model of myocardial infarction.

  • 5

    The findings contribute to understanding SJP's molecular mechanisms and support its clinical application in managing acute myocardial infarction.

Original Source(s)

Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study

  • by Yugen Shi, Wenjing Yi, Xue Feng, Qingshan Zhang, Shuai Bao, Li Sun, Suhua Yan, Nannan Li, Xiaolu Li

  • July 16, 2026

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