-
1
Diffuse gliomas are the most common aggressive primary brain tumors in adults, with a 5-year survival rate of only 10% despite aggressive treatment.
-
2
Maximal safe surgical resection significantly improves progression-free and overall survival, with a minimum extent of resection of 70–78% suggested for survival advantage.
-
3
Supramarginal resection, which includes non-enhancing tumor areas, has been associated with improved overall survival compared to resection of only contrast-enhancing tumors.
-
4
Intraoperative technologies such as neuronavigation and functional mapping are developed to optimize extent of resection while preserving neurological function.
-
5
Local drug delivery strategies, like Gliadel® wafers, bypass the blood-brain barrier, allowing high concentrations of chemotherapy directly into the tumor resection cavity.
