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1
The authors dispute the claim that a PMX-20R cartridge approaches endotoxin saturation after a 2-hour session.
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2
In closed-loop experiments, the 2-hour plateau followed a single 15-µg LPS spike and reflected adsorption–desorption equilibrium, not demonstrated saturation.
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3
A separate experiment recovered about 20 µg of LPS from a cartridge after a 100-µg load, but its 2-hour endpoint did not establish saturation.
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4
In a 24-hour continuous-loading model using a neonatal cartridge, cumulative LPS adsorption reached 4.73 µg without saturation, equivalent by fiber-mass scaling to 66.2 µg for an adult cartridge.
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5
The authors note that prolonged PMX treatment is used in Japan, while its optimal duration and clinical benefits, particularly for patients with EA values of 0.90 or higher, remain undetermined.
