A modified frailty index to identify high-risk groups for amyotrophic lateral sclerosis - Takeaways - MDSpire

A modified frailty index to identify high-risk groups for amyotrophic lateral sclerosis

  • By

  • Xuecai Gao

  • Sheng Chen

  • Sarwara Mahabub

  • Baokun Cao

  • Jiahe Deng

  • Weimin Ye

  • Haomin Yang

  • Zhangyu Zou

  • July 15, 2026

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  • 1

    The study developed a modified frailty index (MFI) to identify high-risk populations for amyotrophic lateral sclerosis (ALS).

  • 2

    Five significant health deficits were identified in the frailty index that are associated with ALS, including falls and self-rated health.

  • 3

    Both the frailty index (FI) and MFI showed a higher risk of ALS, with hazard ratios of 4.58 and 4.59, respectively.

  • 4

    A combination of MFI, gender, age, and BMI provided the best discriminative ability for ALS risk, achieving a C-index of 0.696.

  • 5

    The study utilized a large cohort from the UK Biobank, including 500,033 participants, to validate the risk stratification tools.

Original Source(s)

A modified frailty index to identify high-risk groups for amyotrophic lateral sclerosis

  • by Xuecai Gao, Sheng Chen, Sarwara Mahabub, Baokun Cao, Jiahe Deng, Weimin Ye, Haomin Yang, Zhangyu Zou

  • July 15, 2026

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